Title：
Mass spectrometry based translational proteomics for biomarker discovery and application in colorectal cancer
Authors：
Corresponding
Author：
Hong Ma, Guilin Chen, Mingquan Guo*
Pubyear：
2016
Title of
Journal：
Proteomics Clin. Appl.
Paper
Code：
Volume：
10
Number：
Page：
503–515
Others：
Classification：
Source：
Abstract：
Colorectal cancer (CRC) is a leading cause of cancer-related death in the world. Clinically, early detection of the disease is the most effective approach to tackle this tough challenge. Discovery and development of reliable and effective diagnostic tools for the assessment of prognosis and prediction of response to drug therapy are urgently needed for personalized therapies and better treatment outcomes.Among many ongoing efforts in search for potentialCRCbiomarkers,MSbased ranslational proteomics provides a unique opportunity for the discovery and application of protein biomarkers toward better CRC early detection and treatment. This review updates most recent studies that use preclinical models and clinical materials for the identification of CRC-related protein markers. Some new advances in the development of CRC proteinmarkers such as CRC stem cell related protein markers, SRM/MRM-MS and MS cytometry approaches are also discussed in order to address future directions and challenges from bench translational research to bedside clinical application of CRC biomarkers.
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