Resume：

• 2022.03 -	Principal Investigator as Pharmacology of medicinal plant group in theKey Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences.
  2017.11 - 2021.11	University of Florida, postdoctoral
  2017.02 - 2017.10	Albany Medical College, postdoctoral
  2014.07 - 2017.01	Wuhan Institute of Virology, Chinese Academy of Sciences, Assistant researcher
  2011.09 - 2014.07	Wuhan Botanical Garden, Chinese Academy of Sciences, Doctor of Botany
  2008.09 - 2011.07	Wuhan Institute of Virology, Chinese Academy of Sciences, Master of Biochemistry and molecular biology
  2004.09 - 2008.07	Hubei University of traditional Chinese medicine, Bachelor of Pharmaceutical Engineering

Professional specialty：

• 1) Taking gut and gut microbiota as new targets, to study the mechanism of medicinal plants inhypertension control.

  2) To screen and identify new leader compounds lowering blood pressurefrom medicinal plants.

  3) To study the mechanism of medicinal plants, intestinal microbial ecology andgut，and their interaction in the prevention and development of hypertension.

  4) Focusing on the secondary metabolism of medicinal plants and the biotransformation of gut microbiota, to investigate the molecular mechanism of biosynthesis of key active molecules and developrelated products.

Funded projects：

Academic service：

Members：

Aawards and honors：

Major publications：

• 1. Li J, Richards EM, Handberg, EM, Pepine CJ and Raizada MK. 2021. Butyrate Regulates COVID-19-Relevant Genes in Gut Epithelial Organoids from Normotensive Rats. Hypertension,77(2): e13-e16.
  2. Li J, Stevens BR, Richards EM, Raizada MK. 2022. SARS-CoV-2 Receptor ACE2 (Angiotensin-Converting Enzyme 2) Is Upregulated in Colonic Organoids From Hypertensive Rats. Hypertension, 76(3): e26-e28.
  3. Li J, Ge Y, Zadeh M, Curtiss III R, Mohamadzadeh M. 2020. Regulating vitamin B12 biosynthesis via the cbiMCbl riboswitch in Propionibacterium strain UF1. Proceedings of the National Academy of Sciences, 117(1): 602-609.
  4. Li J, Richards EM, Tummala R, Pepine CJ, Raizada MK and Yang T. 2023. Host‐Microbiota Communication in Spontaneously Hypertensive Rats Generates Unique IgA‐Coated Gut Microbes. Journal of the American Heart Association, e027918.
  5. Li J, Richards EM, Handberg EM, Pepine CJ, Alakrad E, Forsmark CE and Raizada, MK. 2023. Influence of Butyrate on Impaired Gene Expression in Colon from Patients with High Blood Pressure. International Journal of Molecular Sciences, 24(3): 2650.
  6. Huang C^*, Deng W^*, Xu HZ, Zhou C, Zhang F, Chen J, Bao Q, Zhou X, Liu M, Li J^* and Liu C^*. 2023. Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells. Computational and Structural Biotechnology Journal, published online.
  7. Huang C, Xu H, Zhou X, Liu M, Li J^*, Liu C^*. 2022. Systematic Investigations on the Metabolic and Transcriptomic Regulation of Lactate in the Human Colon Epithelial Cells. International Journal of Molecular Sciences, 23(11): 6262.
  8. Li J, Richards EM, Handberg EM, Pepine CJ, Raizada MK. 2021. Distinct Gene Expression Profiles in Colonic Organoids from Normotensive and the Spontaneously Hypertensive Rats. Cells, 10(6): 1523.
  9. Li J, Raizada MK, Richards EM. 2021. Gut–brain–bone marrow axis in hypertension. Current Opinion in Nephrology and Hypertension, 30(2): 159-165.
  10. Li J, Huang C, Zheng D, Wang Y and Yuan Z. 2012. CcpA-mediated enhancement of sugar and amino acid metabolism in Lysinibacillussphaericus by NMR-based metabolomics. Journal of Proteome Research, 11.9: 4654–4661.
  11. Li J, Zhang Y. 2014. Increase of betulinic acid production in Saccharomyces cerevisiae by balancing fatty acids and betulinic acid forming pathways. Applied Microbiology and Biotechnology, 98: 3081-3089.
  12. Li J, Zhang Y. 2015. Modulating betulinic acid production in Saccharomyces cerevisiae by managing the intracellular supplies of the co-factor NADPH and oxygen. Journal of bioscience and bioengineering, 119.1: 77-81.
  13. Li J, Su Q, Karas MM, Richards EM, Raizada MK. 2020. Colonic Crypt‐Derived 3D Gut Organoid from Hypertensive Rat Maintain In vivo Characteristics. The FASEB Journal, 34(S1): 1-1.
  14. Zhou C^*, Li J^*, Li C, Zhang Y. 2016. Improvement of betulinic acid biosynthesis in yeast using multiple strategies. BMC Biotechnology, 16:59.